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Latest in Hair Loss News
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Scientists at USC identify new mechanism that controls activation of hair stem cells - Jan 14, 2008
Group of researchers at the University of Southern California (USC) have identified new mechanism that controls cyclic activation of hair follicle stem cells. They have shown that signaling proteins - BMPs (bone morphogenetic proteins) provide basis for coordinated stem cell activity during hair regeneration. This study is published in the Jan. 17 issue of the journal Nature: Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration
Findings revealed in the study have important implications for stem cell research and in understanding how stem cell activity is regulated during regeneration, says Dr. Cheng-Ming Chuong, principal investigator and professor of pathology at USC.
“Hairs are an important model for organ regeneration in mammals because it is one of the only organs that regenerates on a regular basis,” Chuong says. “The research presents major possibilities for hair re-growth and ultimately organ regeneration.”
Mice on this picture form curiously shaped patterns of regenerating hairs due to the newly identified mechanism of macro-environmental control of hair follicle stem cells activation
By studying hair regeneration cycles in animal models, researchers found that hairs tended to regenerate as large groups, rather than individually (see on the accompanying picture). The findings suggest that stem cells are not regulated only within one hair, as has previously been thought, but also by neighboring hairs and skin dermis, says Dr. Maksim Plikus, the lead author of the study.
Expression of BMPs in the skin macro-environment appears to activate the mechanism for hair stem cell coordination. When many hairs regenerate, they must communicate activation signals amongst themselves. At different times the macro-environment can be either permissive or suppressive of stem cell activity.
“Our research shows that formation of new tissues or organs from stem cells—such as the formation of new hairs — can be more robust if it occurs in a permissive skin macro-environment,” Dr. Maksim Plikus says. “I hope that our research will draw more attention to the hair follicle as the model for physiological regeneration in mammals, and as an abundant source of adult stem cells.”
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Hair Loss News Archive
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Scientists at USC identify new mechanism that controls activation of hair stem cells - Jan 14, 2008
2007 year-end clinical trial update from Intercytex - Dec 30, 2007
Using human hair follicle bulge cells Chinese researches constructed skin suitable for wound repair - Dec 28, 2007
Researches found potent precursor cells of neuronal lineage in dermal papilla of adult hairs - Sep 27, 2007
News study reports that wounded adult skin can regenerate new hair follicles. - May 16, 2007
HairMax LaserComb receives FDA clearance - February 14, 2007
Upcoming European Hair Research Society 2006 Annual Meeting - June 12, 2006
Intercytex Ltd. performs first human phase I Study on Follicular Cell Implantation in Manchester, UK - June 12, 2006
Aderans institute report their progress on hair cloning - January 18, 2006
Loss of stem cells causes hair graying - March 14, 2005
Interview with Dr. Lu Zhongfa - January 19, 2005
Dr Gho's clinic has financial problems - December 28, 2004
Tooth cells can induce formation of new hairs - December 28, 2004
Surprising report on human hair cloning comes from China - November 25, 2004
Do hair stem cells form blood vessels? - October 21, 2004
Human follicular stem cells: their presence in plucked hair and follicular cell culture - June 2, 2004
Adult hair follicle stem cells can be used to clone new hairs - March 15, 2004
Hairier mouse with longer penis overexpressed gene-called Noggin - March 2, 2004
Sawaya on the *real* story behind hair loss research - March 2, 2004
Hair follicle dermal cells can form bone and fat tissue - January 15, 2004
New hairs from bone marrow - December 2, 2003
LG 70-2 - potential new hair growth stimulators - June 18, 2003
Highlights of Upcoming SID Meeting - April 20, 2003
CD34 - New marker for hair stem cells. New tool for gene therapy and tissue engineering - April 3, 2003
Regeneration of a new hair follicle from the upper half of a human hair - November 8, 2002
Hair dermal papillae and dermal sheath cells can give rise to blood stem cells - October 23, 2002
Dermal papilla gene expression profile - September 16, 2002
Cell proliferation and death in male pattern baldness - August 29, 2002
Highlights of 63rd Annual Meeting of Society of Investigative Dermatology - Part II - June 17, 2002
Highlights of 63rd Annual Meeting of Society of Investigative Dermatology - Part I - May 31, 2002
Pigment stem cells in hair follice - May 6, 2002
Skin epithelila cells can originate from hematopoietic stem cells - April 9, 2002
Opinion of experts - March 15, 2002
Stem cells are present in mouse hair follicle bulb - February 27, 2002
Inhibition of beta-cat/Lef1 pathway in skin - January 30, 2002
Cloned hairlines - bisection of hair follicles - January 30, 2002
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